Post Graduate Medical Institute  / Lahore General Hospital / Ameer-ud-Din Medical College,  Lahore,  Pakistan

INFECTION PREVENTION & CONTROL GUIDELINES guidelines

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Infectious Disease & MDROs



Infection agent:

Human immune deficiency virus (HIV)

Precautions:

Standard




Transmission route:

Person-to-person by sexual contact,percutaneous inoculation (eg ,needle stick injury), infected blood or blood products, and verticaltransmission(from mother to child).

Infectivity Period:

lifelong (till viremia lasts)

Patients with HIV infection must not donate blood, plasma, or organs for transplant, tissue cells, or semen for artifical insemination.

Infectious Agent:

Actinomyces israeli.

Precautions:

Standard




Transmission route

Endogenous.

Infectivity period:

No human to human spread.

The natural reservoir is the human mouth and gut (commensal).

Infectious Agent:

Entamoeba hystolitica.

Precautions:

Standard




Transmission route:

Fecal–oral route, ingestion of fecal contaminated food or water containing amoebic cyst.

Infectivity period:

As long as cysts appear in feces (can be for months to years).

Infectious Agent:

Aspergillus spp

Precautions:

Standard




Transmission route:

Caused by inhalation of Aspergillus spp.spores, usually associated with building work

Infectivity period:

No human to human spread.Ubiquitous within the environment

Infectious Agent:

Candida spp (including Candida auris).

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

Usually endogenous. In hospital spread can occur in special care units (e.g. intensive care, neonatal, transplant, burns, and renal units) by contact with secretions of mouth, skin, vagina, and feces from carriers.

Infectivity period:

As long as source is present.

defences are low(Immunosuppression).

Infectious Agent:

Varicella zoster virus.

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Ariborne


To be followed in addition to Standard Precaution when infection can spread by air (e.g) Tuberculosis.



Transmission route:

Person to person by direct contact, droplet, or airborne spread of vesicle fluid (chicken pox or shingles) or respiratory secretions of chicken pox pts. Indirect contact

from environment, freshly contaminated with discharges from vesicles and mucous membranes of infected people.

Infectivity period:

Susceptible persons should be considered to be infectious 10– 21 days following exposure The patient is infectious from as long as 5 but usually within 1–2 days before

the onset of the rash and continues until all lesions are crusted or scabbed, usually 5 days after the rash appears.

Infectious Agent:

Vibrio cholera.

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

Ingestion of food or water contaminated with feces or vomit of infected person.

Infectivity period:

Until fecal samples are negative (usually few days after clinical recovery or after antibiotic treatment).Carrier states may persist for several months in some cases.

Infectious Agent:

C. difficile.

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.





Transmission route:

Endogenous infection, precipitated by antibiotic therapy due to overgrowth of C. difficile in the gut and toxin production.

Exogenous infection by ingestion of spores from a contaminated environment Person-to-person spread in case of active diarrhea.

Infectivity period:

Duration of diarrhea.

Infectious Agent:

Bacterial infection.

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.





Transmission route:

Contact with the discharge from the conjunctivae or respiratory tracts of infected persons from contaminated fingers, clothing, or other articles.

Infectivity period:

Period of active infection.

Infectious agent:

SARS- CoV 2 virus.

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Droplet


To be followed in addition to Standard Precaution when infection can spread by droplets (e.g) Dipthheria, Pertussis, Pneumonia



Airborne (In case of aerosol generating procedures)


To be followed in addition to Standard Precaution when infection can spread by air (e.g) Tuberculosis.



Transmission route:

Person to person by direct contact, droplet, or airborne spread of respiratory secretions of pts .Spread by indirect contact from environment is very rare.

Infectivity Period:

(mild to moderate dis)Precautions can be discontinued 05 days after symptom settles for at least 24 hours and improvement of other symptoms (severe dis) )

Precautions can be discontinued 10 days after symptom settles for at least 24 hours and improvement of other symptoms.Still evolving (Regular updates at CDC

Website).

Infectious agent:

Cytomegalovirus.


Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

Mucosal contact with infectious tissues, secretions, and excretions (urine, saliva, breast milk, cervical secretions, semen etc) The fetus may be infected in utero or during birth.

Infectivity Period:

Virus is excreted for many months after primary infection and may persist or be episodic for years.After neonatal infection, excretion of virus maybe present for 6 years.

Infectious Agent:

Flaviviruses (serotypes 1, 2, 3 and 4).

Precautions:

Standard (Sleep under mosquito net)




Transmission route:

Bite of infective mosquitoes, especially Aedes aegyptis.

Infectivity period:

No direct person-to-person transmission.

Infectious Agent:

Corynebacterium diphtheria

Precautions:

Standard




Contact (For cutaneous diphtheria)


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Dropletel (For pharyngeal diphtheria)


To be followed in addition to Standard Precaution when infection can spread by droplets (e.g) Dipthheria, Pertussis, Pneumonia



Transmission route:

Direct contact with a patient or carrier, or contact with articles contaminated with discharge from lesions or respiratory secretions of infected people.

Infectivity period:

Until off antibiotics and three negative swabs 24 hours apart or after 14 days of appropriate antibiotic Treatment.

Infectious Agent:

Clostridium perfringens and other anaerobic organisms.

Precautions:

Standard




Transmission route:

By contamination of a wound with soil or faecal material.Acquired from endogenous route.

Infectivity Period:

No person-to-person spread.

Infectious Agent:

Various agents including viral, bacterial and protozoal.

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

Often from contaminated food or water. Person-to-person spread is possible for most infectious causes.

Infectivity Period:

Duration of diarrhea.

Infectious Agent:

N.Gonorrhoea

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

During sexual activity with an infected person

Infectivity Period:

For 24h after the start of effective antibiotic therapy.


Type A




Infectious Agent:

Hepatitis A virus.

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

Fecal-oral.

Infectivity period:

Humans: 7 days before to 7 days after onset of jaundice.



Type B and C




Infectious Agent:

Hepatitis B and Hepatitis C virus.

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

Sexually transmitted or by blood inoculation, e.g. needle stick accident, or shared needles in IV drug misuse.

Infectivity period:

Blood and high-risk body fluids as long as viremia persists.



Type E


Infectious Agent:

Hepatitis E virus.

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

Fecal–oral. Food-borne via drinking water contaminated with feces from infected individuals or animals. Parenteral spread, via blood products and solid organ transplantation.

Infectious Agent:

Herpes simplex virus.

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

Direct transmission by contact with the active lesions/vesicle fluid of infected individuals.

Infectivity period:

Until vesicles are healed.

Infectious Agent:
Varicella virus.
Precautions:
Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Ariborne


To be followed in addition to Standard Precaution when infection can spread by air (e.g) Tuberculosis.


Transmission route:
Endogenous type infection—reactivation of latent varicella infection.
Infectivity period:
Until vesicles are dry and healed.

Infectious Agent:

Staphylococcus, Streptococcus.

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

By direct contact with infected people or indirectly by contaminated articles.

Infectivity period:

For 24 hours after initiation of effective antibiotic therapy.

Infectious Agent:

Influenza virus.

Precautions:

Standard




Droplet


To be followed in addition to Standard Precaution when infection can spread by droplets (e.g) Dipthheria, Pertussis, Pneumonia



Airborne


To be followed in addition to Standard Precaution when infection can spread by air (e.g) Tuberculosis.



Transmission route:

By inhalation or by direct inoculation to the mucous membranes through indirect contact with infectious respiratory secretions.

Infectivity period:

1 day before symptoms develop and up to 5 to 7 days after becoming sick. Most contagious in the first 3-4 days after illness begins.

Infectious Agent:

Plasmodium spp.

Precautions:

Standard (Sleep under mosquito net)




Transmission route:

Mosquito bite and blood transfusion.

Infectivity period:

No direct person-to-person spread.

Infectious Agent:

Measles virus.

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Airborne


To be followed in addition to Standard Precaution when infection can spread by air (e.g) Tuberculosis.



Transmission route:

Close contact and direct inoculation of mucous membranes with secretions of an infected person’s respiratory tract.

Infectivity period:

5 days from the onset of rash.

Infectious Agent:

Coliforms Listeria monocytogenes.

Precautions:

Standard




Transmission route:

Respiratory tract.

Close contact, direct inoculation of mucous membranes.

Infectivity Period

Meningities is categious until at least 24 hours after treatment with affective antibiotic.






Infectious Agent:

Meningococcus.

Precautions:

Standard




Droplet


To be followed in addition to Standard Precaution when infection can spread by droplets (e.g) Dipthheria, Pertussis, Pneumonia



Transmission route:

Respiratory tract.

Close contact,direct inoculation of mucous membranes.

Infectivity Period

For 48 h after start of effective antibiotic.

Visiting by all children should be discontinued.






Infectious Agent:

Haemophilus influenzae

(type b).

Precautions:

Standard




Droplet


To be followed in addition to Standard Precaution when infection can spread by droplets (e.g) Dipthheria, Pertussis, Pneumonia



Transmission route:

Respiratory

Infectivity Period

Duration of illness Close contacts should be given rifampicin as a prophylaxis.






Infectious Agent:

S. pneumoniae

(pneumococcal).

Precautions:

Standard




Transmission route:

Respiratory tract

Infectivity Period

Meningities is categious until at least 24 hours after treatment with affective antibiotic.






Infectious Agent:

Tuberculous.

Precautions:

Standard




Ariborne (as pulmonary TB)


To be followed in addition to Standard Precaution when infection can spread by air (e.g) Tuberculosis.



Transmission route:

Respiratory tract

Infectivity Period

Duration of illness.

Isolate if the patient has open pulmonary TB.

Infectious agent:

Staphylococcus aureus

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

By direct contact with the infected site and indirectly by contact with fomites and the hands of HCWs

Infectivity Period:

Colonized HCWs can be a continuous source.Can exist in environment from days to weeks Pt is source till infection lasts

Infectious Agent:

Coliforms’, Pseudomonas and other Gram-negatives

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

By direct contact with the infected site and indirectly by contact with fomites and the hands of HCWs

Infectivity period:

Can exist on environmental surfaces upto weeks Pt is source till infection lasts

Infectious Agent:

Mumps virus

Precautions:
Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Droplet


To be followed in addition to Standard Precaution when infection can spread by air (e.g) Tuberculosis.



Airborne


To be followed in addition to Standard Precaution when infection can spread by droplets (e.g) Dipthheria, Pertussis, Pneumonia



Transmission route:

Airborne transmission or by droplet spread and direct contact with the saliva of an infected person

Infectivity period:

7 days before to 9 days after onset of parotid swelling. Maximum infectiousness 2 days before to 4 days after the onset of illness

Infectious Agent:

Bacterial or Viral

Precautions:

Standard




Droplet


To be followed in addition to Standard Precaution when infection can spread by droplets (e.g) Dipthheria, Pertussis, Pneumonia



Transmission route:

Infected respiratory secretions

Infectivity period:

Until culture negative after effective antibiotic therapy.Duration of illness in case of viral pneumonia.

Infectious Agent:

Rabies virus

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:
The virus-laden saliva of an infected animal introduced usually by a bite or, a scratch or rarely, through a break in the skin or intact mucous membranes

Infectivity period:

In dogs and cats the period for communication is for the duration of the illness.Transmission from the saliva of an infected person is possible

Infectious Agent:

Corona virus

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Droplet


To be followed in addition to Standard Precaution when infection can spread by droplets (e.g) Dipthheria, Pertussis, Pneumonia



Transmission route:

Person to person by direct contact or droplet spread of respiratory secretions of pts .Spread by indirect contact from environment is very rare.

Infectivity period:

Duration of illness

Infectious Agent:

Sarcoptes scabei

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

By direct contact with infested skin and indirectly by contact with undergarments and bed clothes if these have been contaminated by infested people immediately beforehand

Infectivity period:

Until completion of appropriate treatment

Infectious Agent:

Group A (Strep. pyogenes) Group B (Strep agalctiae) Group C, Group G

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

Throat carriage, respiratory( Group A), and direct contact from infected lesions

Infectivity period:

Until culture negative after effective antibiotic therapy

Infectious agent:

Treponema pallidum

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

Acquired by direct contact with the infectious exudates of obvious or concealed, moist, early lesions of the skin and mucous membranes of infected people, during sexual contact and transplacental.

Infectivity Period:

Whilst moist mucocutaneous lesions of primary and secondary syphilis are present. Patients should be advised to avoid sexual contact until treated. Follow-up and treatment of sexual contact are necessary to prevent onward transmission

Infectious Agent:

Clostridium tetani

Precautions:

Standard




Transmission route:

Direct inoculation from contaminated soil via puncture wound or by injecting contaminated street drugs

Infectivity period:

No human to human transmission

Infectious Agent:

Salmonella typhi Salmonella paratyphi

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

Fecal-oral and by ingestion of contaminated food and water contaminated by feces and urine of patients and carriers.

Person to person spread is common.

Contaminated food especially poultry

Infectivity period:

Convalescent carriers can be a continuous source Duration of Diarrhea in patients.

Infectious Agent:

Enterococcus faecium and E.Facaelis

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

By direct and indirect contact with an infected or colonized person

Infectivity period:

Colonized person can be continuous source.Patient is source till infection.

Infectious Agent:

Bacterial

Precautions:

Standard




Contact


To be followed in addition to Standard Precaution when infection can spread by contact (e.g) Methicillin resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus (VRE), Open wounds.



Transmission route:

Direct and indirect contact

Infectivity period:

Until wound stops draining.

Source: Manual of Infection Prevention and Control by Nizam Damani